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Offer: 571

Odorless and requiring almost no cleaning

Reagent bound to polymer facilitates introduction of protective groups.

Polymer-bound reagent that greatly facilitates the introduction of dithiane protecting groups.

Protective groups have important functions in synthetic organic chemistry. Attaching protective groups to a source substance prevents unintended conversion of the functional group in a chemical reaction. In this way, selective conversion can be achieved of one reactive group in the presence of one or more other such groups. Special sulphur protective groups (dithianes or dithiolanes) also offer a possibility to remove the group and, at the same time, introduce other advantageous groupings into the molecule.

State of the art

Synthesizing these dithiane protective groups normally involves organic sulphur compounds which are highly toxic and extremely odorous. Moreover, the individual target substances must be cleaned carefully, which is not only time-consuming but also means extra financial expense caused by the solvents and separating materials required.


To overcome these drawbacks, KIT scientists of the Institute of Organic Chemistry developed a polymer-bound reagent which greatly facilitates the introduction of dithiane protective groups and allows application in parallel synthesis. An aldehyde or ketone as the source material can thus be converted, by means of the reagent and the addition of a solvent, simply, quickly, and safely into the target molecule carrying the protective group. The reagent invented contains two substances needed in protective group synthesis which, because of their polymer binding, are no longer volatile and thus are less toxic and do not smell. In addition, the polymer material inclusive of the reagents and any byproducts generated can be removed from the reaction mix at minimum expense by filtration and evaporation of the solvent. Use of the reagent bound to the solid phase in most cases permits a synthesis with simplified or no purification at all by separation methods, as the reactions proceed very cleanly and, in most cases, without any byproducts.


Applications of the polymer reagent developed are found in synthetic organic chemistry as protective group and intermediate in the introduction of fluorinated groups for pharmaceutical applications. Existing molecules can be modified accordingly also in very small quantities at little expense in an effort to produce new drugs.

Options for companies

The KIT is looking for partners interested in selling the novel reagent for the introduction of protective groups.

Your contact person for this offer

Jan-Niklas Blötz, Karlsruhe Institute of Technology (KIT)
Innovation Manager New Materials, Climate and Environment, Innovation and Relations Management (IRM)
Phone: +49 721 608-26107


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